The same carcinogen can give rise to tumors of different kinds and locations, depending on the site of application, and a given type of tumor can be caused by different substances. www.efsa.europa.eu. Inhaling Aniline can irritate the nose and throat. LEL: … SPECIAL PRECAUTIONS: Aniline is toxic, poisonous and a potential human carcinogen. Aniline poisoning is characterized by methemoglobin formation in the blood and resulting cyanosis or blue skin. the industry in general does not consider aniline as a risk from a consumer safety perspective. There is no legal or scientific reference or study related safe limit values for aniline. IARC. The approximate minimum lethal dose for a 150 lb. CAS number: 62-53-3 NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. The in vitro enzymatic metabolism of N-nitroso-N-methylaniline was investigated using cytochromes P450 2B1 and P450 2B2, isolated from liver microsomes of rats pretreated with phenobarbital (PB), reconstituted with NADPH-cytochrome P450 reductase and dilauroylphosphatidylcholine. Aniline may therefore cause cancer at even the slightest level of exposure. : 4 (1974) (p. 27) 5. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an … VOL. Some authorities class aniline as a carcinogen, although the IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. Chronic Effects . Beginning of August 2012, 108 agents are classified in Group 1 of IARC. In addition to the concerns related to the genotoxicity and carcinogenicity, it can cause methemoglobinemia and haemolytic anaemia after long term exposure. It is therefore not possible to determine a level of intake for aniline which may be regarded as safe for humans. However, benzidine has not been sold in the United States since the mid-1970s. Its EINECS register number is 200-539-3 and CAS register number is 62-53-3. Aniline can cause methemoglobin formation, and liver and endocrine effects. Aniline CAS RN: 62-53-3 Carcinogenicity Evidence. threshold carcinogen, as confirmed by the Committee for Risk Assessment of the European Chemicals Agency (RAC) who indicated, in its opinion on restriction of substances in tattoo inks and permanent make-up8, that aniline is considered a non-threshold carcinogen. In mice, however, only a marginally positive … Symptoms of methemoglobinemia include cyanosis, headache, dizziness, weakness, lethargy, loss of coordination, dyspnea, coma, and death. o-Toluidine is toxic and a potential human carcinogen. The formation of methemoglobin interferes with the oxygen-carrying capacity of the blood. EPA calculated an inhalation unit risk estimate of 4.9 × 10 -3 (µg/m 3)-1. This category is only used when sufficient indications of carcinogenicity for humans are available. (4) EPA uses mathematical models, based on human and animal studies, to estimate the probability of a person developing cancer from breathing air containing a specified concentration of a chemical. It is toxic and a suspected carcinogen which is readily absorbed by the skin. EPA has classified hydrazine as a Group B2, probable human carcinogen. Aniline can cause skin irritation and rash. The Reportable Quantity (RQ) value of 1, 10, 100, 1000, or 5000 pounds is used to determine the quantity of a hazardous substance for which notification is required in the event of a release as specified by CERCLA based on chronic toxicity. Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. In the past, benzidine was used to produce dyes or products used in clinical laboratories. Given new scientific evidence, it cannot be excluded that aniline ’s carcinogenic potential is due to damage to the genetic material of the cells. Aniline is incompatible with oxidizing agents, bases, acids, iron and iron salts, zinc, aluminium. Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. N-Nitroso-N-methylaniline (NMA) is an esophageal carcinogen in the rat. References ^ Thomas Kahl, Kai-Wilfrid Schröder, "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry 2007; John Wiley & Sons: New York. Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg). Aniline should be handled as a CARCINOGEN--WITH EXTREME CAUTION. 1) Aniline is a skin and eye irritant and a mild dermal sensitizer. Aniline is classified as a suspected carcinogen (carcinogen category 2) under the Classification, Labelling and Packaging Regulation (CLP) in the EU. (A substance that causes cancer or helps cancer grow is called a carcinogen.) GROUP 1: the agent may be a carcinogenic mixture for humans (proven carcinogen or certainly carcinogenic). carcinogen. It is rapidly absorbed by all routes and induces methemoglobinemia. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data There is no adequate data to indicate that aniline is carcinogenic in experimental animals. The exposure circumstance entails exposures that are carcinogenic to humans. Exposure levels at the garment stage, especially those having undergone garment-washing processes, were low. Dietary Supplement Label Database (DSLD): The Dietary Supplement Label Database (DSLD) (https://dsld.od.nih.gov) includes full label derived information from dietary supplement products marketed in the U.S. with a Web-based user interface that provides ready access to label information. Is Aniline Carcinogen? The American Cancer Society looks to these organizations to evaluate the risks based on evidence from laboratory, animal, and human research studies. Until recently, these inadequate experiments plus the publication of a series of epidemiologic studies that exonerated aniline as a bladder carcinogen have led to the belief that aniline is not a carcinogen. Aniline has been evaluated as a carcinogen. Learn about benzidine, exposure to which raises your risk of bladder cancer. Aniline is a colourless, oily liquid which turns brown on exposure to light and air. The process for converting aniline, which has the odor of rotten fish, to a colored dye when treated by acids was discovered by accident in England in 1856. The International Agency for Research on Cancer (IAR Carcinogen List The following is a list of substances NIOSH considers to be potential occupational carcinogens. What are aniline dyes and how did such a plant end up in Nyack? Benzidine is a manufactured chemical. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis Considered a Non Threshold carcinogen : CLASSIFICATION: B2; probable human carcinogen. Aniline is an organic compound with the formula C 6 H 5 NH 2 which has the IUPAC name Phenylamine. aniline in adult man is about 0.21 mg/kg body weight Chronic exposure Anemia, headaches, tremor, parathesia, pain, narcosis or coma, and cardiac arrhythmia. Serious poisoning may result from ingestion of 0.25 mL. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an aromatic amine-like odor. Acetanilide can be produced by reacting acetic anhydride with aniline: C 6 H 5 NH 2 + (CH 3 CO) 2 O → C 6 H 5 NHCOCH 3 + CH 3 COOH. A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 days. But interestingly, we have seen that aniline has started to appear on restricted substance lists, which … 000062-53-3 Aniline 3 27, Sup 7 1987 000090-04-0 ortho-Anisidine 2B Sup 7, 73 1999 000104-94-9 para-Anisidine 3 27, Sup 7 1987 000191-26-4 Anthanthrene 3 92, Sup 7 2010 000120-12-7 Anthracene 3 92, Sup 7 2010 000118-92-3 Anthranilic acid 3 16, Sup 7 1987 000084-65-1 Anthraquinone 2B 101 2013 001309-64-4 Antimony trioxide 2B 47 1989 001345-04-6 Antimony trisulfide 3 47 1989 000052-46-0 … Vapour affects the eyes and lungs and reduces the ability of blood to carry oxygen. In 1978, the results of a carcinogenesis bioassay in rats and mice given aniline hydrochloride were released. Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, … GOTS position on Aniline Aniline is known to possess slight contact sensitising potential. IRIS (U.S. EPA, 2007) has classified aniline as a probable human carcinogen (Group B2), based on an increased incidence of sarcomas of the spleen and other organs in two strains of rats exposed orally to aniline hydrochloride (CIIT,1982; NCI, 1978) and supporting genetic toxicity evidence. Classification of carcinogenicity: Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. Nitrobenzene is toxic and poisonous. ... Metolachlor can increase the incidence of liver tumors in rats and has been classified as a possible human carcinogen (Monsanto, 1991; Wilson and Takei, 1999; Heydens et al., 2010). IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Ethanol is flammable and a dangerous fire risk. Based on animal studies the Panel concluded that aniline should be considered as a carcinogen [ 3 ]. Loading… human is 10 grams. The available studies in humans are inadequate to determine whether exposure to aniline can increase the risk of developing cancer in people. ANILINE. Aniline is a chemical byproduct of treated coal tar, which was an abundant waste product of the time. 5.2 Human carcinogenicity data At the present time, the weight of epidemiological evidence suggests that aniline is not a carcinogen for the human bladder. Azobenzene (AZB) is non-carcinogenic in mice, but a potent rat carcinogen, inducing tumours in the spleen and other abdominal organs. List of Classifications. It is soluble in water, ether, ethanol and most organic solvents. • USEPA: suggests that Aniline could be a suspected carcinogen and there is no evidence of being carcinogenic by itself. This site is now being updated and maintained for access by the NIH Office of Dietary Supplements It is considered to have high acute toxicity, based on short-term animal tests in rats. Aniline can irritate the eyes with possible eye damage. The human carcinogen potency factor (q1*) for aniline is .026 (mg/kg/day)-1 for oral exposure. The present paper shows that AZB clearly induces micronuclei in the bone marrow of rats at a dose of 375 mg/kg and above. NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. Although aniline is "only" a category 2 carcinogen (remember formaldehyde?) A number of the carcinogen classifications deal with groups of substances: aniline and homologs, chromates, dintrotoluenes, arsenic and inorganic arsenic compounds, beryllium and beryllium compounds, cadmium compounds, nickel compounds, and crystalline forms of silica. BUT, rats that ate food contaminated with aniline for life developed cancer of the spleen. The International Agency for Research on Cancer (IARC) determined that aniline is not classifiable as to its carcinogenicity to humans. 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